Human

Human Kidney Gene DataBase
Name cadherin 1, type 1, E-cadherin (epithelial)
Symbol CDH1
Aliases UVO; CDHE; ECAD; LCAM; Arc-1; uvomorulin; cell-CAM 120/80; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial
Gene Product
  • cadherin 1, type 1 preproprotein
Category
UniGene Hs.194657 
Reference Sequence
mRNA: NM_004360 Protein: NP_004351
OMIM and SNP
OMIM: 192090 SNP: NCBI SNP
Locus
LocusLink: 999Chromosome: 16Cytoband: 16q22.1 UCSC Genome Map Eesembl Genome Map
SummaryThis gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Gene Ontology
Expression
EST (477 ESTs, 214 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 32 libraries express this gene (3.12%)Average CPM:1.56
brainBreadth of expression: 3 out of 759 libraries express this gene (0.40%)Average CPM:0.24
colonBreadth of expression: 33 out of 930 libraries express this gene (3.55%)Average CPM:11.09
earBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.67
embryoBreadth of expression: 1 out of 4 libraries express this gene (25.00%)Average CPM:0.77
esophagusBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:1.51
eyeBreadth of expression: 1 out of 24 libraries express this gene (4.17%)Average CPM:0.21
germ cellBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:0.06
head and neckBreadth of expression: 12 out of 680 libraries express this gene (1.76%)Average CPM:123.32
heartBreadth of expression: 2 out of 26 libraries express this gene (7.69%)Average CPM:0.17
kidneyBreadth of expression: 7 out of 145 libraries express this gene (4.83%)Average CPM:12.63
liverBreadth of expression: 5 out of 65 libraries express this gene (7.69%)Average CPM:0.89
lungBreadth of expression: 16 out of 334 libraries express this gene (4.79%)Average CPM:13.98
mammary glandBreadth of expression: 23 out of 1038 libraries express this gene (2.22%)Average CPM:52.41
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:0.39
nervousBreadth of expression: 1 out of 21 libraries express this gene (4.76%)Average CPM:2.17
ovaryBreadth of expression: 4 out of 170 libraries express this gene (2.35%)Average CPM:4.54
pancreasBreadth of expression: 4 out of 20 libraries express this gene (20.00%)Average CPM:1.71
parathyroidBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.91
placentaBreadth of expression: 11 out of 358 libraries express this gene (3.07%)Average CPM:0.20
prostateBreadth of expression: 5 out of 309 libraries express this gene (1.62%)Average CPM:0.27
skinBreadth of expression: 4 out of 38 libraries express this gene (10.53%)Average CPM:3.93
spleenBreadth of expression: 1 out of 15 libraries express this gene (6.67%)Average CPM:0.78
stomachBreadth of expression: 11 out of 310 libraries express this gene (3.55%)Average CPM:0.12
testisBreadth of expression: 1 out of 180 libraries express this gene (0.56%)Average CPM:0.05
thymusBreadth of expression: 1 out of 23 libraries express this gene (4.35%)Average CPM:2.84
thyroidBreadth of expression: 1 out of 48 libraries express this gene (2.08%)Average CPM:4.65
uncharacterized tissueBreadth of expression: 41 out of 1739 libraries express this gene (2.36%)Average CPM:0.14
uterusBreadth of expression: 14 out of 236 libraries express this gene (5.93%)Average CPM:10.33
SAGE (10370711 tags, 207 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:20.61
brainBreadth of expression: 16 out of 30 libraries express this gene (53.33%)Average CPM:25.36
cervixBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:131.50
colonBreadth of expression: 8 out of 8 libraries express this gene (100.00%)Average CPM:453.03
eyeBreadth of expression: 6 out of 6 libraries express this gene (100.00%)Average CPM:59.26
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:35.56
kidneyBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:23.43
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:44.87
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:100.96
mammary glandBreadth of expression: 17 out of 20 libraries express this gene (85.00%)Average CPM:319.33
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:28.42
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:54.13
ovaryBreadth of expression: 4 out of 10 libraries express this gene (40.00%)Average CPM:166.53
pancreasBreadth of expression: 5 out of 8 libraries express this gene (62.50%)Average CPM:262.34
prostateBreadth of expression: 13 out of 14 libraries express this gene (92.86%)Average CPM:202.88
skinBreadth of expression: 5 out of 7 libraries express this gene (71.43%)Average CPM:100.85
stomachBreadth of expression: 4 out of 4 libraries express this gene (100.00%)Average CPM:311.11
uncharacterized tissueBreadth of expression: 18 out of 20 libraries express this gene (90.00%)Average CPM:247.91
vascularBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:35.09
EvidenceCpG Methylation in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco