Human

Human Kidney Gene DataBase
Name lysozyme (renal amyloidosis)
Symbol LYZ
Aliases
Gene Product
  • lysozyme precursor
Category
UniGene Hs.234734 
Reference Sequence
mRNA: NM_000239 Protein: NP_000230
OMIM and SNP
OMIM: 153450 SNP: NCBI SNP
Locus
LocusLink: 4069Chromosome: 12Cytoband: 12q14.3 UCSC Genome Map Eesembl Genome Map
SummaryLYZ encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the anti-microbial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, aliva, and tears. Missense mutations in LYZ have been identified in heritable renal anyloidosis.
Gene Ontology
Expression
EST (1029 ESTs, 168 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.12
bloodBreadth of expression: 2 out of 32 libraries express this gene (6.25%)Average CPM:0.66
boneBreadth of expression: 2 out of 24 libraries express this gene (8.33%)Average CPM:2.94
bone marrowBreadth of expression: 3 out of 22 libraries express this gene (13.64%)Average CPM:3.11
brainBreadth of expression: 6 out of 759 libraries express this gene (0.79%)Average CPM:97.18
cartilageBreadth of expression: 3 out of 16 libraries express this gene (18.75%)Average CPM:0.37
colonBreadth of expression: 18 out of 930 libraries express this gene (1.94%)Average CPM:0.65
esophagusBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.70
eyeBreadth of expression: 1 out of 24 libraries express this gene (4.17%)Average CPM:0.29
germ cellBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:0.03
head and neckBreadth of expression: 27 out of 680 libraries express this gene (3.97%)Average CPM:112.39
heartBreadth of expression: 2 out of 26 libraries express this gene (7.69%)Average CPM:4.52
kidneyBreadth of expression: 3 out of 145 libraries express this gene (2.07%)Average CPM:0.80
liverBreadth of expression: 2 out of 65 libraries express this gene (3.08%)Average CPM:0.10
lungBreadth of expression: 6 out of 334 libraries express this gene (1.80%)Average CPM:0.14
lymph nodeBreadth of expression: 3 out of 22 libraries express this gene (13.64%)Average CPM:2.90
mammary glandBreadth of expression: 3 out of 1038 libraries express this gene (0.29%)Average CPM:1.06
muscleBreadth of expression: 2 out of 83 libraries express this gene (2.41%)Average CPM:1.10
pancreasBreadth of expression: 1 out of 20 libraries express this gene (5.00%)Average CPM:0.31
placentaBreadth of expression: 2 out of 358 libraries express this gene (0.56%)Average CPM:0.03
skinBreadth of expression: 2 out of 38 libraries express this gene (5.26%)Average CPM:1.91
spleenBreadth of expression: 1 out of 15 libraries express this gene (6.67%)Average CPM:0.12
stomachBreadth of expression: 17 out of 310 libraries express this gene (5.48%)Average CPM:1.16
uncharacterized tissueBreadth of expression: 49 out of 1739 libraries express this gene (2.82%)Average CPM:10.23
uterusBreadth of expression: 2 out of 236 libraries express this gene (0.85%)Average CPM:0.22
vascularBreadth of expression: 2 out of 18 libraries express this gene (11.11%)Average CPM:0.19
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:0.71
SAGE (11081014 tags, 196 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:3029.49
brainBreadth of expression: 22 out of 30 libraries express this gene (73.33%)Average CPM:67.32
cervixBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:65.75
colonBreadth of expression: 6 out of 8 libraries express this gene (75.00%)Average CPM:79.96
eyeBreadth of expression: 4 out of 6 libraries express this gene (66.67%)Average CPM:40.20
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:71.13
kidneyBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:58.81
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:59.83
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:3522.43
mammary glandBreadth of expression: 13 out of 20 libraries express this gene (65.00%)Average CPM:97.18
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:170.55
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:162.39
ovaryBreadth of expression: 5 out of 10 libraries express this gene (50.00%)Average CPM:137.41
pancreasBreadth of expression: 4 out of 8 libraries express this gene (50.00%)Average CPM:310.20
prostateBreadth of expression: 9 out of 14 libraries express this gene (64.29%)Average CPM:69.22
skinBreadth of expression: 2 out of 7 libraries express this gene (28.57%)Average CPM:76.21
stomachBreadth of expression: 4 out of 4 libraries express this gene (100.00%)Average CPM:2635.46
uncharacterized tissueBreadth of expression: 16 out of 20 libraries express this gene (80.00%)Average CPM:168.04
vascularBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:42.33
EvidenceMutation in Renal Amyloidosis

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco