Human

Human Kidney Gene DataBase
Name complement component 4A
Symbol C4A
Aliases C4S; CO4; acidic C4; C4A anaphylatoxin; Rodgers form of C4
Gene Product
  • complement component 4A preproprotein
Category
UniGene Hs.150833 
Reference Sequence
mRNA: NM_007293 Protein: NP_009224
OMIM and SNP
OMIM: 120810 SNP: NCBI SNP
Locus
LocusLink: 720Chromosome: 6Cytoband: 6p21.3 UCSC Genome Map Eesembl Genome Map
SummaryThis gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
Gene Ontology
Expression
EST (584 ESTs, 187 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 2 out of 8 libraries express this gene (25.00%)Average CPM:9.96
boneBreadth of expression: 3 out of 24 libraries express this gene (12.50%)Average CPM:0.36
bone marrowBreadth of expression: 1 out of 22 libraries express this gene (4.55%)Average CPM:0.65
brainBreadth of expression: 32 out of 759 libraries express this gene (4.22%)Average CPM:1.75
cartilageBreadth of expression: 3 out of 16 libraries express this gene (18.75%)Average CPM:0.65
colonBreadth of expression: 11 out of 930 libraries express this gene (1.18%)Average CPM:48.92
esophagusBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.62
eyeBreadth of expression: 9 out of 24 libraries express this gene (37.50%)Average CPM:0.93
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:1.61
head and neckBreadth of expression: 3 out of 680 libraries express this gene (0.44%)Average CPM:7.85
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.14
kidneyBreadth of expression: 8 out of 145 libraries express this gene (5.52%)Average CPM:0.70
liverBreadth of expression: 10 out of 65 libraries express this gene (15.38%)Average CPM:2.62
lungBreadth of expression: 11 out of 334 libraries express this gene (3.29%)Average CPM:46.28
lymph nodeBreadth of expression: 2 out of 22 libraries express this gene (9.09%)Average CPM:0.18
mammary glandBreadth of expression: 12 out of 1038 libraries express this gene (1.16%)Average CPM:102.53
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:0.64
nervousBreadth of expression: 5 out of 21 libraries express this gene (23.81%)Average CPM:1.03
ovaryBreadth of expression: 5 out of 170 libraries express this gene (2.94%)Average CPM:2.02
pancreasBreadth of expression: 1 out of 20 libraries express this gene (5.00%)Average CPM:0.32
pineal glandBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:1.79
placentaBreadth of expression: 3 out of 358 libraries express this gene (0.84%)Average CPM:0.16
prostateBreadth of expression: 4 out of 309 libraries express this gene (1.29%)Average CPM:32.31
skinBreadth of expression: 1 out of 38 libraries express this gene (2.63%)Average CPM:0.21
spleenBreadth of expression: 1 out of 15 libraries express this gene (6.67%)Average CPM:1.60
stomachBreadth of expression: 3 out of 310 libraries express this gene (0.97%)Average CPM:0.87
testisBreadth of expression: 3 out of 180 libraries express this gene (1.67%)Average CPM:1.07
uncharacterized tissueBreadth of expression: 38 out of 1739 libraries express this gene (2.19%)Average CPM:0.59
uterusBreadth of expression: 9 out of 236 libraries express this gene (3.81%)Average CPM:1.92
SAGE (2177454 tags, 36 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:20.61
brainBreadth of expression: 9 out of 30 libraries express this gene (30.00%)Average CPM:31.75
colonBreadth of expression: 2 out of 8 libraries express this gene (25.00%)Average CPM:16.94
eyeBreadth of expression: 3 out of 6 libraries express this gene (50.00%)Average CPM:18.96
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:29.91
mammary glandBreadth of expression: 5 out of 20 libraries express this gene (25.00%)Average CPM:20.70
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:56.85
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:36.09
pancreasBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:29.45
uncharacterized tissueBreadth of expression: 5 out of 20 libraries express this gene (25.00%)Average CPM:28.02
EvidenceDeletion in Nephrotic Syndrome

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco