Human

Human Kidney Gene DataBase
Name non-metastatic cells 1, protein (NM23A) expressed in
Symbol NME1
Aliases AWD; GAAD; NM23; NDPKA; NM23-H1
Gene Product
  • nucleoside-diphosphate kinase 1 isoform a
  • nucleoside-diphosphate kinase 1 isoform b
Category
UniGene Hs.118638 
Reference Sequence
mRNA: NM_198175 Protein: NP_937818
OMIM and SNP
OMIM: 156490 SNP: NCBI SNP
Locus
LocusLink: 4830Chromosome: 17Cytoband: 17q21.3 UCSC Genome Map Eesembl Genome Map
SummaryNME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. NME1 encodes the 'A' isoform of nucleoside diphosphate kinase (NDK). NDK exists as a hexamer composed of the 'A' (NME1) and 'B' (encoded by NME2) isoforms. Mutations in NME1 have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene.
Gene Ontology
Expression
EST (604 ESTs, 218 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 5 out of 32 libraries express this gene (15.62%)Average CPM:1.09
boneBreadth of expression: 3 out of 24 libraries express this gene (12.50%)Average CPM:0.42
bone marrowBreadth of expression: 4 out of 22 libraries express this gene (18.18%)Average CPM:1.68
brainBreadth of expression: 21 out of 759 libraries express this gene (2.77%)Average CPM:0.41
cartilageBreadth of expression: 2 out of 16 libraries express this gene (12.50%)Average CPM:0.52
cervixBreadth of expression: 2 out of 11 libraries express this gene (18.18%)Average CPM:0.34
colonBreadth of expression: 15 out of 930 libraries express this gene (1.61%)Average CPM:12.32
embryoBreadth of expression: 1 out of 4 libraries express this gene (25.00%)Average CPM:0.61
eyeBreadth of expression: 5 out of 24 libraries express this gene (20.83%)Average CPM:0.90
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:0.58
head and neckBreadth of expression: 4 out of 680 libraries express this gene (0.59%)Average CPM:2.09
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.22
kidneyBreadth of expression: 8 out of 145 libraries express this gene (5.52%)Average CPM:0.44
liverBreadth of expression: 9 out of 65 libraries express this gene (13.85%)Average CPM:2.06
lungBreadth of expression: 12 out of 334 libraries express this gene (3.59%)Average CPM:0.63
lymph nodeBreadth of expression: 5 out of 22 libraries express this gene (22.73%)Average CPM:1.80
mammary glandBreadth of expression: 9 out of 1038 libraries express this gene (0.87%)Average CPM:8.76
muscleBreadth of expression: 3 out of 83 libraries express this gene (3.61%)Average CPM:0.15
nervousBreadth of expression: 3 out of 21 libraries express this gene (14.29%)Average CPM:1.60
oral cavityBreadth of expression: 2 out of 13 libraries express this gene (15.38%)Average CPM:0.19
ovaryBreadth of expression: 3 out of 170 libraries express this gene (1.76%)Average CPM:23.99
pancreasBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:0.89
parathyroidBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.24
pineal glandBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:1.74
placentaBreadth of expression: 7 out of 358 libraries express this gene (1.96%)Average CPM:3.27
prostateBreadth of expression: 7 out of 309 libraries express this gene (2.27%)Average CPM:0.21
skinBreadth of expression: 8 out of 38 libraries express this gene (21.05%)Average CPM:0.40
stomachBreadth of expression: 14 out of 310 libraries express this gene (4.52%)Average CPM:0.09
synoviumBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:1.28
testisBreadth of expression: 5 out of 180 libraries express this gene (2.78%)Average CPM:0.19
uncharacterized tissueBreadth of expression: 36 out of 1739 libraries express this gene (2.07%)Average CPM:0.67
uterusBreadth of expression: 8 out of 236 libraries express this gene (3.39%)Average CPM:15.33
vascularBreadth of expression: 3 out of 18 libraries express this gene (16.67%)Average CPM:0.73
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:1.73
SAGE (20144964 tags, 393 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:20.61
brainBreadth of expression: 30 out of 30 libraries express this gene (100.00%)Average CPM:237.12
cerebellumBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:195.01
colonBreadth of expression: 8 out of 8 libraries express this gene (100.00%)Average CPM:184.75
eyeBreadth of expression: 5 out of 6 libraries express this gene (83.33%)Average CPM:477.47
foreskinBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:102.47
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:71.13
kidneyBreadth of expression: 3 out of 3 libraries express this gene (100.00%)Average CPM:508.36
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:149.56
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:100.96
mammary glandBreadth of expression: 19 out of 20 libraries express this gene (95.00%)Average CPM:374.74
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:170.55
muscleBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:46.41
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:216.52
ovaryBreadth of expression: 9 out of 10 libraries express this gene (90.00%)Average CPM:356.97
pancreasBreadth of expression: 6 out of 8 libraries express this gene (75.00%)Average CPM:287.02
prostateBreadth of expression: 14 out of 14 libraries express this gene (100.00%)Average CPM:395.01
skinBreadth of expression: 7 out of 7 libraries express this gene (100.00%)Average CPM:352.07
stomachBreadth of expression: 4 out of 4 libraries express this gene (100.00%)Average CPM:248.94
uncharacterized tissueBreadth of expression: 19 out of 20 libraries express this gene (95.00%)Average CPM:294.11
vascularBreadth of expression: 3 out of 3 libraries express this gene (100.00%)Average CPM:261.50
EvidenceDeletion in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco