Human

Human Kidney Gene DataBase
Name chemokine (C-C motif) ligand 2
Symbol CCL2
Aliases HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; MGC9434; GDCF-2 HC11; monocyte secretory protein JE; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; small inducible cytokine subfamily A (Cys-Cys), member 2; monocyte chemotactic protein 1, homologous to mouse Sig-je
Gene Product
  • small inducible cytokine A2 precursor
Category
UniGene Hs.303649 
Reference Sequence
mRNA: NM_002982 Protein: NP_002973
OMIM and SNP
OMIM: 158105 SNP: NCBI SNP
Locus
LocusLink: 6347Chromosome: 17Cytoband: 17q11.2-q21.1 UCSC Genome Map Eesembl Genome Map
SummaryThis gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Gene Ontology
Expression
EST (228 ESTs, 104 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.54
bloodBreadth of expression: 2 out of 32 libraries express this gene (6.25%)Average CPM:2.24
boneBreadth of expression: 5 out of 24 libraries express this gene (20.83%)Average CPM:1.11
bone marrowBreadth of expression: 1 out of 22 libraries express this gene (4.55%)Average CPM:0.61
brainBreadth of expression: 6 out of 759 libraries express this gene (0.79%)Average CPM:0.21
cartilageBreadth of expression: 6 out of 16 libraries express this gene (37.50%)Average CPM:0.87
colonBreadth of expression: 5 out of 930 libraries express this gene (0.54%)Average CPM:1.20
eyeBreadth of expression: 4 out of 24 libraries express this gene (16.67%)Average CPM:1.36
germ cellBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:0.36
head and neckBreadth of expression: 3 out of 680 libraries express this gene (0.44%)Average CPM:3.99
heartBreadth of expression: 2 out of 26 libraries express this gene (7.69%)Average CPM:1.79
kidneyBreadth of expression: 4 out of 145 libraries express this gene (2.76%)Average CPM:1.03
liverBreadth of expression: 3 out of 65 libraries express this gene (4.62%)Average CPM:0.33
lungBreadth of expression: 11 out of 334 libraries express this gene (3.29%)Average CPM:0.59
mammary glandBreadth of expression: 2 out of 1038 libraries express this gene (0.19%)Average CPM:2.40
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:0.82
pancreasBreadth of expression: 3 out of 20 libraries express this gene (15.00%)Average CPM:1.47
placentaBreadth of expression: 1 out of 358 libraries express this gene (0.28%)Average CPM:1.55
prostateBreadth of expression: 1 out of 309 libraries express this gene (0.32%)Average CPM:0.17
skinBreadth of expression: 2 out of 38 libraries express this gene (5.26%)Average CPM:0.82
stomachBreadth of expression: 1 out of 310 libraries express this gene (0.32%)Average CPM:0.25
testisBreadth of expression: 3 out of 180 libraries express this gene (1.67%)Average CPM:0.10
uncharacterized tissueBreadth of expression: 26 out of 1739 libraries express this gene (1.50%)Average CPM:31.78
uterusBreadth of expression: 1 out of 236 libraries express this gene (0.42%)Average CPM:0.30
vascularBreadth of expression: 2 out of 18 libraries express this gene (11.11%)Average CPM:12.75
whole bodyBreadth of expression: 2 out of 12 libraries express this gene (16.67%)Average CPM:0.36
SAGE (6039987 tags, 108 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 24 out of 30 libraries express this gene (80.00%)Average CPM:87.48
cervixBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:131.50
colonBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:16.55
eyeBreadth of expression: 3 out of 6 libraries express this gene (50.00%)Average CPM:28.52
foreskinBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:307.41
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:82.98
kidneyBreadth of expression: 1 out of 3 libraries express this gene (33.33%)Average CPM:22.97
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:74.78
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:201.92
mammary glandBreadth of expression: 5 out of 20 libraries express this gene (25.00%)Average CPM:460.62
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:85.27
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:108.26
ovaryBreadth of expression: 4 out of 10 libraries express this gene (40.00%)Average CPM:157.06
pancreasBreadth of expression: 3 out of 8 libraries express this gene (37.50%)Average CPM:99.91
prostateBreadth of expression: 7 out of 14 libraries express this gene (50.00%)Average CPM:50.42
skinBreadth of expression: 1 out of 7 libraries express this gene (14.29%)Average CPM:65.93
stomachBreadth of expression: 2 out of 4 libraries express this gene (50.00%)Average CPM:38.09
uncharacterized tissueBreadth of expression: 13 out of 20 libraries express this gene (65.00%)Average CPM:119.30
vascularBreadth of expression: 3 out of 3 libraries express this gene (100.00%)Average CPM:227.57
EvidencePolymorphism in Lupus Nephritis

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco