| Name | apolipoprotein A-I |
| Symbol | APOA1 |
| Aliases | |
| Gene Product | - apolipoprotein A-I precursor
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| Category | |
| UniGene |
Hs.93194
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| Reference Sequence |
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| OMIM and SNP |
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| Locus |
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| Summary | APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the C-III gene is transcribed convergently in relation to A-I. Defects in the apolipoprotein A-1 gene are associated with HDL deficiency and Tangier disease. |
| Gene Ontology | |
| Expression | | EST (557 ESTs, 58 libraries) |
| Tissue | Breadth ? |
CPM ? |
| brain |  | | | colon | | | | germ cell | | | | heart | | | | liver | | | | lung | | | | muscle | | | | ovary | | | | pancreas | | | | placenta | | | | spleen | | | | testis | | | | thymus | | | | uncharacterized tissue | | | | whole body | | |
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| SAGE (1264119 tags, 24 libraries) |
| Tissue | Breadth ? |
CPM ? |
| brain | | | | colon | | | | heart | | | | kidney |  | | | liver | | | | mammary gland | | | | ovary | | | | prostate | | | | skin | | | | stomach | | | | uncharacterized tissue | | | | vascular | | |
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| Evidence | Mutation in Renal Amyloidosis
- Vigushin DM, Gough J, Allan D, Alguacil A, Penner B, Pettigrew NM, Quinonez G, Bernstein K, Booth SE, Booth DR, et al. Familial nephropathic systemic amyloidosis caused by apolipoprotein AIvariant Arg26. Q J Med 1994 Mar;87(3):149-54.
Other key publications related to this gene
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