Human

Human Kidney Gene DataBase
Name matrix metalloproteinase 1 (interstitial collagenase)
Symbol MMP1
Aliases CLG; CLGN; fibroblast collagenase; interstitial collagenase
Gene Product
  • matrix metalloproteinase 1 preproprotein
Category
UniGene Hs.83169 
Reference Sequence
mRNA: NM_002421 Protein: NP_002412
OMIM and SNP
OMIM: 120353 SNP: NCBI SNP
Locus
LocusLink: 4312Chromosome: 11Cytoband: 11q22.3 UCSC Genome Map Eesembl Genome Map
SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Gene Ontology
Expression
EST (165 ESTs, 54 libraries)
Tissue Breadth ? CPM ?
boneBreadth of expression: 2 out of 24 libraries express this gene (8.33%)Average CPM:2.96
cartilageBreadth of expression: 2 out of 16 libraries express this gene (12.50%)Average CPM:11.48
colonBreadth of expression: 4 out of 930 libraries express this gene (0.43%)Average CPM:4.28
esophagusBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:4.36
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:0.17
head and neckBreadth of expression: 4 out of 680 libraries express this gene (0.59%)Average CPM:15.15
lungBreadth of expression: 4 out of 334 libraries express this gene (1.20%)Average CPM:1.70
mammary glandBreadth of expression: 1 out of 1038 libraries express this gene (0.10%)Average CPM:0.84
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:2.83
ovaryBreadth of expression: 1 out of 170 libraries express this gene (0.59%)Average CPM:0.49
pancreasBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:5.60
placentaBreadth of expression: 1 out of 358 libraries express this gene (0.28%)Average CPM:8.16
skinBreadth of expression: 2 out of 38 libraries express this gene (5.26%)Average CPM:6.78
stomachBreadth of expression: 2 out of 310 libraries express this gene (0.65%)Average CPM:0.68
uncharacterized tissueBreadth of expression: 14 out of 1739 libraries express this gene (0.81%)Average CPM:3.53
uterusBreadth of expression: 3 out of 236 libraries express this gene (1.27%)Average CPM:24.84
vascularBreadth of expression: 3 out of 18 libraries express this gene (16.67%)Average CPM:9.77
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:0.49
SAGE (10772700 tags, 212 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:20.61
brainBreadth of expression: 26 out of 30 libraries express this gene (86.67%)Average CPM:67.23
cerebellumBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:19.50
colonBreadth of expression: 6 out of 8 libraries express this gene (75.00%)Average CPM:38.32
eyeBreadth of expression: 4 out of 6 libraries express this gene (66.67%)Average CPM:62.41
foreskinBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:259.00
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:11.85
kidneyBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:27.38
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:14.96
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:22.44
mammary glandBreadth of expression: 15 out of 20 libraries express this gene (75.00%)Average CPM:183.07
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:56.85
muscleBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:37.14
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:36.09
ovaryBreadth of expression: 9 out of 10 libraries express this gene (90.00%)Average CPM:1592.27
pancreasBreadth of expression: 4 out of 8 libraries express this gene (50.00%)Average CPM:98.81
prostateBreadth of expression: 9 out of 14 libraries express this gene (64.29%)Average CPM:39.87
skinBreadth of expression: 4 out of 7 libraries express this gene (57.14%)Average CPM:657.62
stomachBreadth of expression: 3 out of 4 libraries express this gene (75.00%)Average CPM:160.84
uncharacterized tissueBreadth of expression: 16 out of 20 libraries express this gene (80.00%)Average CPM:693.57
vascularBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:94.85
EvidencePolymorphism in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco