| Name | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
| Symbol | CDKN2B |
| Aliases | P15; MTS2; TP15; INK4B; p14_INK4B; p15_INK4B; CDK4B inhibitor; p14_CDK inhibitor; p15 CDK inhibitor; CDK inhibitory protein; multiple tumor suppressor 2; cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinases 4 and 6 binding protein |
| Gene Product | - cyclin-dependent kinase inhibitor 2B isoform 1
- cyclin-dependent kinase inhibitor 2B isoform 2
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| Category | |
| UniGene |
Hs.72901
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| Reference Sequence |
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| OMIM and SNP |
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| Locus |
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| Summary | This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
| Gene Ontology | |
| Expression | | EST (55 ESTs, 43 libraries) |
| Tissue | Breadth ? |
CPM ? |
| brain |  | | | cartilage | | | | cervix | | | | colon | | | | head and neck | | | | kidney |  | | | liver | | | | lung | | | | mammary gland | | | | muscle | | | | pancreas | | | | prostate | | | | skin | | | | stomach | | | | testis | | | | uncharacterized tissue | | | | uterus | | |
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| SAGE (926300 tags, 19 libraries) |
| Tissue | Breadth ? |
CPM ? |
| brain | | | | colon | | | | eye | | | | kidney | | | | mammary gland | | | | ovary | | | | prostate | | | | skin | | | | uncharacterized tissue | | |
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| Evidence | CpG Methylation in Kidney Neoplasms
- Tanaka T, Iwasa Y, Kondo S, Hiai H, Toyokuni S, Tanaka T, Iwasa Y, Kondo S, Hiai H, Toyokuni S, Tanaka T, Iwasa Y, Kondo S, Hiai H, Toyokuni S High incidence of allelic loss on chromosome 5 and inactivation ofp15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renalcell carcinoma of rats. Oncogene 1999 Jun 24;18(25):3793-7.
Other key publications related to this gene
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