Name | tumor necrosis factor (TNF superfamily, member 2) |
Symbol | TNF |
Aliases | DIF; TNFA; TNFSF2; CACHECTIN; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor, alpha (cachectin) |
Gene Product | - tumor necrosis factor alpha
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Category | |
UniGene |
Hs.241570
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Reference Sequence |
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OMIM and SNP |
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Locus |
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Summary | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
Gene Ontology | |
Expression | EST (82 ESTs, 26 libraries) |
Tissue | Breadth ? |
CPM ? |
blood |  |  | brain |  |  | cartilage |  |  | colon |  |  | heart |  |  | lung |  |  | lymph node |  |  | ovary |  |  | placenta |  |  | prostate |  |  | stomach |  |  | testis |  |  | uncharacterized tissue |  |  |
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SAGE (6310978 tags, 114 libraries) |
Tissue | Breadth ? |
CPM ? |
blood |  |  | brain |  |  | cerebellum |  |  | colon |  |  | eye |  |  | heart |  |  | kidney |  |  | lung |  |  | mammary gland |  |  | mesothelial tissue |  |  | muscle |  |  | nervous |  |  | ovary |  |  | pancreas |  |  | prostate |  |  | skin |  |  | stomach |  |  | uncharacterized tissue |  |  | vascular |  |  |
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Evidence | Mutation in Kidney Neoplasms
Other key publications related to this gene
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