Human

Human Kidney Gene DataBase

Name tumor necrosis factor (TNF superfamily, member 2)
Symbol TNF
Aliases DIF; TNFA; TNFSF2; CACHECTIN; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor, alpha (cachectin)
Gene Product
  • tumor necrosis factor alpha
Category
UniGene Hs.241570 
Reference Sequence
mRNA: NM_000594 Protein: NP_000585
OMIM and SNP
OMIM: 191160 SNP: NCBI SNP
Locus
LocusLink: 7124Chromosome: 6Cytoband: 6p21.3 UCSC Genome Map Eesembl Genome Map
SummaryThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Gene Ontology
Expression
EST (82 ESTs, 26 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 2 out of  32 libraries express this gene (6.25%)Average CPM:8.76
brainBreadth of expression: 1 out of  759 libraries express this gene (0.13%)Average CPM:31.19
cartilageBreadth of expression: 1 out of  16 libraries express this gene (6.25%)Average CPM:2.81
colonBreadth of expression: 1 out of  930 libraries express this gene (0.11%)Average CPM:20.43
heartBreadth of expression: 1 out of  26 libraries express this gene (3.85%)Average CPM:0.66
lungBreadth of expression: 1 out of  334 libraries express this gene (0.30%)Average CPM:0.36
lymph nodeBreadth of expression: 1 out of  22 libraries express this gene (4.55%)Average CPM:1.41
ovaryBreadth of expression: 1 out of  170 libraries express this gene (0.59%)Average CPM:2.86
placentaBreadth of expression: 1 out of  358 libraries express this gene (0.28%)Average CPM:0.91
prostateBreadth of expression: 1 out of  309 libraries express this gene (0.32%)Average CPM:7.95
stomachBreadth of expression: 1 out of  310 libraries express this gene (0.32%)Average CPM:9.70
testisBreadth of expression: 1 out of  180 libraries express this gene (0.56%)Average CPM:41.48
uncharacterized tissueBreadth of expression: 10 out of  1739 libraries express this gene (0.58%)Average CPM:96.02
SAGE (6310978 tags, 114 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:123.65
brainBreadth of expression: 19 out of  30 libraries express this gene (63.33%)Average CPM:48.17
cerebellumBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:39.00
colonBreadth of expression: 5 out of  8 libraries express this gene (62.50%)Average CPM:25.59
eyeBreadth of expression: 4 out of  6 libraries express this gene (66.67%)Average CPM:51.97
heartBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:11.85
kidneyBreadth of expression: 2 out of  3 libraries express this gene (66.67%)Average CPM:54.77
lungBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:78.53
mammary glandBreadth of expression: 11 out of  20 libraries express this gene (55.00%)Average CPM:73.51
mesothelial tissueBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:28.42
muscleBreadth of expression: 2 out of  2 libraries express this gene (100.00%)Average CPM:37.13
nervousBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:36.09
ovaryBreadth of expression: 4 out of  10 libraries express this gene (40.00%)Average CPM:66.40
pancreasBreadth of expression: 3 out of  8 libraries express this gene (37.50%)Average CPM:60.15
prostateBreadth of expression: 6 out of  14 libraries express this gene (42.86%)Average CPM:70.42
skinBreadth of expression: 1 out of  7 libraries express this gene (14.29%)Average CPM:86.48
stomachBreadth of expression: 4 out of  4 libraries express this gene (100.00%)Average CPM:32.35
uncharacterized tissueBreadth of expression: 10 out of  20 libraries express this gene (50.00%)Average CPM:33.28
vascularBreadth of expression: 2 out of  3 libraries express this gene (66.67%)Average CPM:15.18
EvidenceMutation in Kidney Neoplasms

Other key publications related to this gene


© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco