Name | tumor necrosis factor (TNF superfamily, member 2) |
Symbol | TNF |
Aliases | DIF; TNFA; TNFSF2; CACHECTIN; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor, alpha (cachectin) |
Gene Product | - tumor necrosis factor alpha
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Category | |
UniGene |
Hs.241570
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Reference Sequence |
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OMIM and SNP |
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Locus |
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Summary | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
Gene Ontology | |
Expression | EST (82 ESTs, 26 libraries) |
Tissue | Breadth ? |
CPM ? |
blood | | | brain | | | cartilage | | | colon | | | heart | | | lung | | | lymph node | | | ovary | | | placenta | | | prostate | | | stomach | | | testis | | | uncharacterized tissue | | |
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SAGE (6310978 tags, 114 libraries) |
Tissue | Breadth ? |
CPM ? |
blood | | | brain | | | cerebellum | | | colon | | | eye | | | heart | | | kidney | | | lung | | | mammary gland | | | mesothelial tissue | | | muscle | | | nervous | | | ovary | | | pancreas | | | prostate | | | skin | | | stomach | | | uncharacterized tissue | | | vascular | | |
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Evidence | Mutation in Kidney Neoplasms
Other key publications related to this gene
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