Human

Human Kidney Gene DataBase
Name thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Symbol THRB
Aliases GRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; ERBA-BETA; oncogene ERBA2; generalized resistance to thyroid hormone; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2
Gene Product
  • thyroid hormone receptor, beta
Category
UniGene Hs.203213 
Reference Sequence
mRNA: NM_000461 Protein: NP_000452
OMIM and SNP
OMIM: 190160 SNP: NCBI SNP
Locus
LocusLink: 7068Chromosome: 3Cytoband: 3p24.3 UCSC Genome Map Eesembl Genome Map
SummaryThe protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
Gene Ontology
Expression
EST (108 ESTs, 52 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:1.14
brainBreadth of expression: 12 out of 759 libraries express this gene (1.58%)Average CPM:4.14
cartilageBreadth of expression: 1 out of 16 libraries express this gene (6.25%)Average CPM:2.42
colonBreadth of expression: 2 out of 930 libraries express this gene (0.22%)Average CPM:1.17
earBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.74
eyeBreadth of expression: 4 out of 24 libraries express this gene (16.67%)Average CPM:52.91
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.75
kidneyBreadth of expression: 2 out of 145 libraries express this gene (1.38%)Average CPM:1.20
liverBreadth of expression: 1 out of 65 libraries express this gene (1.54%)Average CPM:7.52
lungBreadth of expression: 3 out of 334 libraries express this gene (0.90%)Average CPM:32.60
mammary glandBreadth of expression: 4 out of 1038 libraries express this gene (0.39%)Average CPM:1.28
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:4.33
oral cavityBreadth of expression: 1 out of 13 libraries express this gene (7.69%)Average CPM:1.08
ovaryBreadth of expression: 1 out of 170 libraries express this gene (0.59%)Average CPM:1.29
pancreasBreadth of expression: 1 out of 20 libraries express this gene (5.00%)Average CPM:0.43
placentaBreadth of expression: 1 out of 358 libraries express this gene (0.28%)Average CPM:1.23
prostateBreadth of expression: 3 out of 309 libraries express this gene (0.97%)Average CPM:782.47
stomachBreadth of expression: 1 out of 310 libraries express this gene (0.32%)Average CPM:50.32
uncharacterized tissueBreadth of expression: 8 out of 1739 libraries express this gene (0.46%)Average CPM:1.93
vascularBreadth of expression: 2 out of 18 libraries express this gene (11.11%)Average CPM:1.84
SAGE (3131672 tags, 53 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 12 out of 30 libraries express this gene (40.00%)Average CPM:27.15
colonBreadth of expression: 4 out of 8 libraries express this gene (50.00%)Average CPM:36.34
eyeBreadth of expression: 3 out of 6 libraries express this gene (50.00%)Average CPM:15.89
foreskinBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:105.30
mammary glandBreadth of expression: 5 out of 20 libraries express this gene (25.00%)Average CPM:26.25
muscleBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:18.56
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:18.04
ovaryBreadth of expression: 1 out of 10 libraries express this gene (10.00%)Average CPM:20.58
prostateBreadth of expression: 6 out of 14 libraries express this gene (42.86%)Average CPM:40.39
stomachBreadth of expression: 2 out of 4 libraries express this gene (50.00%)Average CPM:38.30
uncharacterized tissueBreadth of expression: 5 out of 20 libraries express this gene (25.00%)Average CPM:54.03
EvidenceMutation in Kidney Neoplasms

Other key publications related to this gene

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Department of Urology
University of California, San Francisco