| Name | catenin (cadherin-associated protein), beta 1, 88kDa |
| Symbol | CTNNB1 |
| Aliases | CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); catenin (cadherin-associated protein), beta 1 (88kDa |
| Gene Product | - catenin (cadherin-associated protein), beta 1, 88kDa
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| Category | |
| UniGene |
Hs.410086
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| Reference Sequence |
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| OMIM and SNP |
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| Locus |
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| Summary | Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM] |
| Gene Ontology | |
| Expression | | EST (513 ESTs, 245 libraries) |
| Tissue | Breadth ? |
CPM ? |
| blood |  | | | bone | | | | bone marrow | | | | brain | | | | cerebellum | | | | cervix | | | | colon | | | | ear | | | | embryo | | | | eye | | | | germ cell | | | | head and neck | | | | heart | | | | kidney |  | | | liver | | | | lung | | | | lymph node | | | | mammary gland | | | | muscle | | | | nervous | | | | oral cavity | | | | ovary | | | | pancreas | | | | parathyroid | | | | placenta | | | | prostate | | | | skin | | | | spleen | | | | stomach | | | | testis | | | | thyroid | | | | uncharacterized tissue | | | | uterus | | | | vascular | | | | whole body | | |
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| Evidence | Mutation in Kidney Neoplasms
- Kim YS, Kang YK, Kim JB, Han SA, Kim KI, Paik SR, Kim YS, Kang YK, Kim JB, Han SA, Kim KI, Paik SR beta-catenin expression and mutational analysis in renal cell carcinomas. Pathol Int 2000 Sep;50(9):725-30.
- Maiti S, Alam R, Amos CI, Huff V Frequent association of beta-catenin and WT1 mutations in Wilms tumors. Cancer Res 2000 Nov 15;60(22):6288-92.
- Koesters R, Ridder R, Kopp-Schneider A, Betts D, Adams V, Niggli F, Briner J, von Knebel Doeberitz M Mutational activation of the beta-catenin proto-oncogene is a common eventin the development of Wilms' tumors. Cancer Res 1999 Aug 15;59(16):3880-2.
Other key publications related to this gene
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