| Name | met proto-oncogene (hepatocyte growth factor receptor) |
| Symbol | MET |
| Aliases | HGFR; RCCP2; Oncogene MET |
| Gene Product | - met proto-oncogene precursor
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| Category | |
| UniGene |
Hs.419124
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| Reference Sequence |
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| OMIM and SNP |
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| Locus |
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| Summary | The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. |
| Gene Ontology | |
| Expression | | EST (287 ESTs, 124 libraries) |
| Tissue | Breadth ? |
CPM ? |
| adipose |  | | | bone | | | | bone marrow | | | | brain | | | | cartilage | | | | cervix | | | | colon | | | | ear | | | | eye | | | | head and neck | | | | heart | | | | kidney |  | | | liver | | | | lung | | | | lymph node | | | | mammary gland | | | | muscle | | | | oral cavity | | | | ovary | | | | placenta | | | | prostate | | | | skin | | | | spleen | | | | stomach | | | | thyroid | | | | uncharacterized tissue | | | | uterus | | | | vascular | | | | whole body | | |
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| Evidence | Mutation in Kidney Neoplasms
- Schmidt L, Junker K, Nakaigawa N, Kinjerski T, Weirich G, Miller M, Lubensky I, Neumann HP, Brauch H, Decker J, Vocke C, Brown JA, Jenkins R, Richard S, Bergerheim U, Gerrard B, Dean M, Linehan WM, Zbar B Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene 1999 Apr 8;18(14):2343-50.
- Schmidt L, Junker K, Weirich G, Glenn G, Choyke P, Lubensky I, Zhuang Z, Jeffers M, Vande Woude G, Neumann H, Walther M, Linehan WM, Zbar B Two North American families with hereditary papillary renal carcinoma andidentical novel mutations in the MET proto-oncogene. Cancer Res 1998 Apr 15;58(8):1719-22.
- Schmidt L, Duh FM, Chen F, Kishida T, Glenn G, Choyke P, Scherer SW, Zhuang Z, Lubensky I, Dean M, Allikmets R, Chidambaram A, Bergerheim UR, Feltis JT, Casadevall C, Zamarron A, Bernues M, Richard S, Lips CJ, Walther MM, Tsui LC, Geil L, Orcutt ML, Stackhouse T, Zbar B, et al. Germline and somatic mutations in the tyrosine kinase domain of the METproto-oncogene in papillary renal carcinomas. Nat Genet 1997 May;16(1):68-73.
- Olivero M, Valente G, Bardelli A, Longati P, Ferrero N, Cracco C, Terrone C, Rocca-Rossetti S, Comoglio PM, Di Renzo MF Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinasein a HPRCC family. Int J Cancer 1999 Aug 27;82(5):640-3.
Other key publications related to this gene
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