Name | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
Symbol | ABCB1 |
Aliases | CLCS; MDR1; P-gp; PGY1; ABC20; CD243; GP170; P glycoprotein 1; colchicin sensitivity; doxorubicin resistance; multidrug resistance 1 |
Gene Product | - ATP-binding cassette sub-family B member 1
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Category | |
UniGene |
Hs.21330
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Reference Sequence |
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OMIM and SNP |
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Locus |
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Summary | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. |
Gene Ontology | |
Expression | EST (64 ESTs, 37 libraries) |
Tissue | Breadth ? |
CPM ? |
brain | | | colon | | | eye | | | kidney | | | liver | | | mammary gland | | | muscle | | | nervous | | | placenta | | | prostate | | | skin | | | testis | | | uncharacterized tissue | | | uterus | | |
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SAGE (2211947 tags, 41 libraries) |
Tissue | Breadth ? |
CPM ? |
brain | | | cerebellum | | | colon | | | eye | | | kidney | | | liver | | | mammary gland | | | ovary | | | pancreas | | | prostate | | | stomach | | | uncharacterized tissue | | |
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Evidence | Polymorphism in Kidney Neoplasms
Other key publications related to this gene
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