| Name | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| Symbol | CYP1A1 |
| Aliases | AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX; P450 form 6; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 |
| Gene Product | - cytochrome P450, family 1, subfamily A, polypeptide 1
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| Category | |
| UniGene |
Hs.72912
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| Reference Sequence |
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| OMIM and SNP |
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| Locus |
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| Summary | This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. |
| Gene Ontology | |
| Expression | | EST (45 ESTs, 31 libraries) |
| Tissue | Breadth ? |
CPM ? |
| adipose |  | | | blood | | | | bone | | | | brain | | | | cartilage | | | | cervix | | | | colon | | | | liver | | | | lung | | | | mammary gland | | | | nervous | | | | prostate | | | | skin | | | | testis | | | | uncharacterized tissue | | |
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| SAGE (2107960 tags, 39 libraries) |
| Tissue | Breadth ? |
CPM ? |
| brain | | | | cerebellum | | | | colon | | | | eye | | | | kidney |  | | | liver | | | | mammary gland | | | | ovary | | | | prostate | | | | uncharacterized tissue | | | | vascular | | |
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| Evidence | Polymorphism in Kidney Neoplasms
- Longuemaux S, Delomenie C, Gallou C, Mejean A, Vincent-Viry M, Bouvier R, Droz D, Krishnamoorthy R, Galteau MM, Junien C, Beroud C, Dupret JM Candidate genetic modifiers of individual susceptibility to renal cellcarcinoma: a study of polymorphic human xenobiotic-metabolizing enzymes. Cancer Res 1999 Jun 15;59(12):2903-8.
Other key publications related to this gene
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