Human

Human Kidney Gene DataBase
Name angiotensin II receptor, type 1
Symbol AGTR1
Aliases AT1; AG2S; AT1B; AT2R1; HAT1R; AGTR1A; AGTR1B; AT2R1A; AT2R1B; angiotensin receptor 1; angiotensin receptor 1B; type-1B angiotensin II receptor
Gene Product
  • angiotensin II receptor, type 1
Category
UniGene Hs.89472  Hs.197063 
Reference Sequence
mRNA: NM_032049 Protein: NP_114438
OMIM and SNP
OMIM: 106165 SNP: NCBI SNP
Locus
LocusLink: 185Chromosome: 3Cytoband: 3q21-q25 UCSC Genome Map Eesembl Genome Map
SummaryAngiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene AGTR1B exists; however, it is now believed that there is only one AGTR1 gene. The gene expresses at least four transcript variants; additional variants have been described but their full length nature has not been determined. Exon 5 contains the entire coding sequence and is present in all transcript variants.
Gene Ontology
Expression
EST (27 ESTs, 15 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 2 out of 759 libraries express this gene (0.26%)Average CPM:0.77
cartilageBreadth of expression: 1 out of 16 libraries express this gene (6.25%)Average CPM:8.40
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:1.03
head and neckBreadth of expression: 1 out of 680 libraries express this gene (0.15%)Average CPM:87.80
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:1.00
kidneyBreadth of expression: 2 out of 145 libraries express this gene (1.38%)Average CPM:2.76
liverBreadth of expression: 1 out of 65 libraries express this gene (1.54%)Average CPM:15.12
lungBreadth of expression: 1 out of 334 libraries express this gene (0.30%)Average CPM:3.05
mammary glandBreadth of expression: 2 out of 1038 libraries express this gene (0.19%)Average CPM:2429.71
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:1.38
nervousBreadth of expression: 2 out of 21 libraries express this gene (9.52%)Average CPM:1.84
placentaBreadth of expression: 3 out of 358 libraries express this gene (0.84%)Average CPM:1.37
testisBreadth of expression: 1 out of 180 libraries express this gene (0.56%)Average CPM:0.86
uncharacterized tissueBreadth of expression: 3 out of 1739 libraries express this gene (0.17%)Average CPM:1.52
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:1.50
SAGE (262711 tags, 5 libraries)
Tissue Breadth ? CPM ?
colonBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:20.38
eyeBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:18.63
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:14.96
mammary glandBreadth of expression: 1 out of 20 libraries express this gene (5.00%)Average CPM:207.25
uncharacterized tissueBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:40.94
vascularBreadth of expression: 1 out of 3 libraries express this gene (33.33%)Average CPM:13.13
EvidencePolymorphism in End-Stage Renal Disease

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco