Human

Human Kidney Gene DataBase
Name cyclin D1 (PRAD1: parathyroid adenomatosis 1)
Symbol CCND1
Aliases BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1
Gene Product
  • cyclin D1
Category
UniGene Hs.371468 
Reference Sequence
mRNA: NM_053056 Protein: NP_444284
OMIM and SNP
OMIM: 168461 SNP: NCBI SNP
Locus
LocusLink: 595Chromosome: 11Cytoband: 11q13 UCSC Genome Map Eesembl Genome Map
SummaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Gene Ontology
Expression
EST (655 ESTs, 245 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.38
boneBreadth of expression: 6 out of 24 libraries express this gene (25.00%)Average CPM:0.58
brainBreadth of expression: 16 out of 759 libraries express this gene (2.11%)Average CPM:4.05
cartilageBreadth of expression: 7 out of 16 libraries express this gene (43.75%)Average CPM:0.29
cervixBreadth of expression: 3 out of 11 libraries express this gene (27.27%)Average CPM:0.63
colonBreadth of expression: 18 out of 930 libraries express this gene (1.94%)Average CPM:36.35
embryoBreadth of expression: 1 out of 4 libraries express this gene (25.00%)Average CPM:0.28
eyeBreadth of expression: 10 out of 24 libraries express this gene (41.67%)Average CPM:0.54
germ cellBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:0.36
head and neckBreadth of expression: 11 out of 680 libraries express this gene (1.62%)Average CPM:5.57
heartBreadth of expression: 2 out of 26 libraries express this gene (7.69%)Average CPM:0.62
kidneyBreadth of expression: 6 out of 145 libraries express this gene (4.14%)Average CPM:2.67
liverBreadth of expression: 8 out of 65 libraries express this gene (12.31%)Average CPM:1.34
lungBreadth of expression: 18 out of 334 libraries express this gene (5.39%)Average CPM:0.36
lymph nodeBreadth of expression: 4 out of 22 libraries express this gene (18.18%)Average CPM:0.16
mammary glandBreadth of expression: 20 out of 1038 libraries express this gene (1.93%)Average CPM:0.21
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:0.14
nervousBreadth of expression: 6 out of 21 libraries express this gene (28.57%)Average CPM:0.61
ovaryBreadth of expression: 6 out of 170 libraries express this gene (3.53%)Average CPM:1.93
pancreasBreadth of expression: 6 out of 20 libraries express this gene (30.00%)Average CPM:4.65
parathyroidBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.07
placentaBreadth of expression: 8 out of 358 libraries express this gene (2.23%)Average CPM:0.05
prostateBreadth of expression: 9 out of 309 libraries express this gene (2.91%)Average CPM:0.39
skinBreadth of expression: 11 out of 38 libraries express this gene (28.95%)Average CPM:0.25
stomachBreadth of expression: 8 out of 310 libraries express this gene (2.58%)Average CPM:0.26
testisBreadth of expression: 2 out of 180 libraries express this gene (1.11%)Average CPM:0.07
thyroidBreadth of expression: 3 out of 48 libraries express this gene (6.25%)Average CPM:5.12
uncharacterized tissueBreadth of expression: 36 out of 1739 libraries express this gene (2.07%)Average CPM:0.15
uterusBreadth of expression: 7 out of 236 libraries express this gene (2.97%)Average CPM:0.07
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:0.25
EvidenceAmplification in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco