Human

Human Kidney Gene DataBase
Name cytochrome P450, family 2, subfamily E, polypeptide 1
Symbol CYP2E1
Aliases CPE1; CYP2E; P450-J; P450C2E; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible); cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
Gene Product
  • cytochrome P450, family 2, subfamily E, polypeptide 1
Category
UniGene Hs.75183 
Reference Sequence
mRNA: NM_000773 Protein: NP_000764
OMIM and SNP
OMIM: 124040 SNP: NCBI SNP
Locus
LocusLink: 1571Chromosome: 10Cytoband: 10q24.3-qter UCSC Genome Map Eesembl Genome Map
SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Gene Ontology
Expression
EST (224 ESTs, 35 libraries)
Tissue Breadth ? CPM ?
boneBreadth of expression: 1 out of 24 libraries express this gene (4.17%)Average CPM:0.99
brainBreadth of expression: 5 out of 759 libraries express this gene (0.66%)Average CPM:1.11
liverBreadth of expression: 9 out of 65 libraries express this gene (13.85%)Average CPM:17.05
lungBreadth of expression: 4 out of 334 libraries express this gene (1.20%)Average CPM:0.31
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:0.41
nervousBreadth of expression: 1 out of 21 libraries express this gene (4.76%)Average CPM:0.55
ovaryBreadth of expression: 2 out of 170 libraries express this gene (1.18%)Average CPM:0.53
testisBreadth of expression: 1 out of 180 libraries express this gene (0.56%)Average CPM:0.10
thymusBreadth of expression: 1 out of 23 libraries express this gene (4.35%)Average CPM:1.41
uncharacterized tissueBreadth of expression: 5 out of 1739 libraries express this gene (0.29%)Average CPM:0.52
uterusBreadth of expression: 1 out of 236 libraries express this gene (0.42%)Average CPM:0.29
SAGE (4353623 tags, 69 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:41.22
brainBreadth of expression: 12 out of 30 libraries express this gene (40.00%)Average CPM:22.63
cervixBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:65.75
colonBreadth of expression: 4 out of 8 libraries express this gene (50.00%)Average CPM:18.37
eyeBreadth of expression: 4 out of 6 libraries express this gene (66.67%)Average CPM:54.68
kidneyBreadth of expression: 1 out of 3 libraries express this gene (33.33%)Average CPM:23.89
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:6775.25
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:11.22
mammary glandBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:19.26
muscleBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:18.56
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:36.09
ovaryBreadth of expression: 5 out of 10 libraries express this gene (50.00%)Average CPM:26.23
pancreasBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:31.03
prostateBreadth of expression: 5 out of 14 libraries express this gene (35.71%)Average CPM:21.38
skinBreadth of expression: 1 out of 7 libraries express this gene (14.29%)Average CPM:44.51
stomachBreadth of expression: 2 out of 4 libraries express this gene (50.00%)Average CPM:15.37
uncharacterized tissueBreadth of expression: 5 out of 20 libraries express this gene (25.00%)Average CPM:22.09
vascularBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:18.13
EvidenceCpG Methylation in Abnormal Kidney Development
  • Vieira I, Pasanen M, Raunio H, Cresteil T Expression of CYP2E1 in human lung and kidney during development and infull-term placenta: a differential methylation of the gene is involved inthe regulation process. Pharmacol Toxicol 1998 Nov;83(5):183-7.

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco