| Name | v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog |
| Symbol | KRAS2 |
| Aliases | KRAS; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; oncogene KRAS2; c-K-ras protein; K-ras p21 protein; c-Kirsten-ras protein; PR310 c-K-ras oncogene; transforming protein p21; cellular c-Ki-ras2 proto-oncogene; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog |
| Gene Product | - c-K-ras2 protein isoform a
- c-K-ras2 protein isoform b
|
| Category | |
| UniGene |
Hs.412107
Hs.447488
|
| Reference Sequence |
|
| OMIM and SNP |
|
| Locus |
|
| Summary | This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. |
| Gene Ontology | |
| Expression | | EST (258 ESTs, 130 libraries) |
| Tissue | Breadth ? |
CPM ? |
| blood |  | | | bone | | | | bone marrow | | | | brain | | | | cartilage | | | | cervix | | | | colon | | | | ear | | | | embryo | | | | germ cell | | | | head and neck | | | | heart | | | | kidney |  | | | lung | | | | lymph node | | | | mammary gland | | | | muscle | | | | nervous | | | | ovary | | | | pancreas | | | | parathyroid | | | | placenta | | | | prostate | | | | skin | | | | spleen | | | | stomach | | | | testis | | | | uncharacterized tissue | | | | uterus | | | | whole body | | |
|
|
| Evidence | Amplification in Kidney Neoplasms
Mutation in Kidney Neoplasms
- Rochlitz CF, Peter S, Willroth G, de Kant E, Lobeck H, Huhn D, Herrmann R Mutations in the ras protooncogenes are rare events in renal cell cancer. Eur J Cancer 1992;28(2-3):333-6.
- Skalkeas GD, Spandidos DA, Kostakis A, Balafouta-Tseleni S, Choremi E, Iliopoulos D, Haliassos A K-ras oncogene mutations in neoplasias of kidney transplanted patients:preliminary results with a new technique. Anticancer Res 1991 Nov-Dec;11(6):2091-3.
- Capella G, Cronauer-Mitra S, Pienado MA, Perucho M Frequency and spectrum of mutations at codons 12 and 13 of the c-K-rasgene in human tumors. Environ Health Perspect 1991 Jun;93:125-31.
Other key publications related to this gene
|
