Human

Human Prostate Gene DataBase

Name steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Symbol SRD5A2
Aliases steroid 5-alpha-reductase 2
Gene Product
  • 3-oxo-5 alpha-steroid 4-dehydrogenase 2
Category
  • Gross deletion in Prostate cancer
  • Mutation in Prostate cancer
  • Polymorphism in Prostate cancer
UniGeneHs.1989
OMIM264600
Locus6716
SummarySteroid 5-alpha reductase 2 is a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. This isoform is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
Gene Ontology
Expression
EST (16 ESTs, 6 libraries)
Tissue ? Frequency ? Count ?
brain (1/204)0.339 1/362011
eye (1/33)0.624 3/93836
lung (1/312)0.532 1/245386
prostate (1/291)1.000 7/109871
uncharacterized tissue (2/1773)0.673 4/713325
SAGE (350564 tags, 6 libraries)
Tissue ? Frequency ? Count ?
brain (3/19)0.494 3/194379
pancreas (1/8)0.922 1/33957
prostate (1/13)0.526 1/59553
uncharacterized tissue (1/22)1.000 2/62675
SNPrs725631 (A/C:mrna-utr);  rs632148 (C/G:mrna-utr);  rs523349 (C/G:mrna-utr);  rs522638 (G/A:mrna-utr);  rs494302 (G/A:mrna-utr);  rs479847 (C/T:mrna-utr);  rs806645 (C/T:locus-region);  rs2300696 (T/C:mrna-utr);  rs519704 (A/G:mrna-utr);  rs619857 (T/C:mrna-utr);  rs542070 (T/G:mrna-utr);  rs493165 (T/A:mrna-utr);  rs2281546 (T/G:mrna-utr);  rs1042578 (G/A:mrna-utr);  rs765138 (A/C:mrna-utr);  rs372319 (G/A:intron);  rs413836 (G/A:mrna-utr);  rs2754530 (T/C:mrna-utr);  rs2666408 (A/T:mrna-utr);  rs2208531 (G/A:mrna-utr);  rs2268794 (T/G:mrna-utr);  
EvidenceGross deletion in Prostate cancer Mutation in Prostate cancer Polymorphism in Prostate cancer

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Department of Urology
Universityof California, San Francisco