Human

Human Prostate Gene DataBase
Name epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Symbol EGFR
Aliases ERBB; Epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
Gene Product
  • epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Category
  • Amplification in Prostate cancer
UniGeneHs.77432
OMIM131550
Locus1956
SummaryEpidermal growth factor receptor; tyrosine kinase, binds to epidermal growth factor (EGF), activates phosphatidylinositol and ras signaling pathways, also involved in actin rearrangement resulting in membrane ruffling
Gene Ontology
Expression
EST (292 ESTs, 126 libraries)
Tissue ? Frequency ? Count ?
brain (9/204)0.004 21/362011
cervix (2/7)0.005 2/28115
colon (7/853)0.014 8/165626
embryo (1/19)0.001 1/37976
eye (4/33)0.025 6/93836
germ cell (2/7)0.001 2/57383
head and neck (9/990)0.237 10/79796
heart (1/22)0.001 1/55494
kidney (4/86)0.002 4/132968
lung (10/312)0.011 25/245386
muscle (3/21)0.009 5/71297
nervous (3/475)0.089 5/43438
oral cavity (1/18)0.097 1/44567
ovary (2/144)0.021 9/81880
placenta (28/342)1.000 76/157762
prostate (4/291)0.001 18/109871
stomach (4/312)0.005 7/129930
testis (2/171)0.001 2/117531
uncharacterized tissue (22/1773)0.007 77/713325
uterus (5/212)0.003 8/155110
SAGE (5643398 tags, 105 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)0.066 1/48523
brain (15/19)0.274 164/1406187
cerebellum (1/1)0.374 12/51280
colon (5/8)0.097 13/367355
eye (4/6)0.036 6/477023
heart (1/1)0.057 3/84357
kidney (2/2)0.088 4/73935
liver (1/1)0.024 1/66861
lung (1/1)0.036 2/89143
mammary gland (8/19)0.093 19/539464
muscle (2/2)1.000 67/215478
ovary (5/10)0.166 8/222623
pancreas (6/8)0.050 7/225310
prostate (7/13)0.074 15/697859
skin (3/7)0.213 5/42082
stomach (1/3)0.091 4/70433
uncharacterized tissue (12/22)0.221 78/702566
vascular (3/3)0.045 6/262919
SNPrs712829 (T/C:locus-region);  rs737540 (A/G:locus-region);  rs1024745 (A/G:locus-region);  rs2241054 (G/C:locus-region);  rs1344307 (A/G:locus-region);  rs1534130 (C/T:locus-region);  rs2331013 (A/G:locus-region);  rs747322 (C/G:locus-region);  rs951854 (A/C:locus-region);  rs2110285 (T/C:locus-region);  rs940813 (C/T:locus-region);  rs1140475 (T/C:locus-region);  rs3065295 (CC/-:locus-region);  rs1558542 (A/G:locus-region);  rs723526 (A/G:locus-region);  rs1468727 (C/T:locus-region);  rs1830063 (C/T:locus-region);  rs949936 (C/T:locus-region);  rs954936 (A/T:locus-region);  rs2270247 (G/T:locus-region);  rs2072453 (C/T:locus-region);  rs1965543 (A/G:locus-region);  rs884904 (A/G:locus-region);  rs845545 (A/G:locus-region);  rs2037698 (C/T:locus-region);  rs4051 (C/T:locus-region);  rs940803 (C/T:locus-region);  rs1997083 (A/T:locus-region);  rs1554718 (C/T:locus-region);  rs1015793 (A/G:locus-region);  rs980653 (C/T:locus-region);  rs883117 (C/T:locus-region);  rs1468724 (C/T:locus-region);  rs768149 (A/G:locus-region);  rs3063035 (-/AA:locus-region);  rs2006704 (G/T:locus-region);  rs917879 (A/G:locus-region);  rs2692450 (G/A:locus-region);  rs2293347 (G/A:locus-region);  rs2280653 (T/C:locus-region);  rs2302534 (G/A:locus-region);  rs2472520 (C/T:locus-region);  rs884225 (A/G:locus-region);  rs3088198 (A/T:locus-region);  rs718836 (A/T:locus-region);  rs1880623 (A/G:locus-region);  rs1013127 (C/T:locus-region);  rs2330950 (A/C:locus-region);  rs884419 (A/G:locus-region);  rs1063486 (G/A:locus-region);  rs984654 (C/T:locus-region);  rs1111650 (C/T:locus-region);  rs759158 (A/C:locus-region);  rs2075101 (A/G:locus-region);  rs2877259 (A/G:locus-region);  rs763317 (A/G:locus-region);  rs868254 (C/G:locus-region);  rs2041645 (C/G:locus-region);  rs741151 (A/G:locus-region);  rs1357973 (G/T:locus-region);  rs1404908 (A/G:locus-region);  rs7334 (C/A:locus-region);  rs1815156 (C/T:locus-region);  rs884686 (A/G:locus-region);  rs1861002 (C/G:locus-region);  rs1525643 (C/T:locus-region);  rs2058502 (C/T:locus-region);  rs729949 (A/G:locus-region);  rs726399 (T/G:locus-region);  rs2017000 (A/G:locus-region);  rs887824 (A/C/AA/-:locus-region);  rs730437 (A/C:locus-region);  rs954311 (C/T:locus-region);  rs2192293 (T/C:locus-region);  rs2740573 (G/T:locus-region);  rs2286962 (A/C:locus-region);  
EvidenceAmplification in Prostate cancer
© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco