| Name | B-cell CLL/lymphoma 2 |
| Symbol | BCL2 |
| Aliases | |
| Gene Product | - B-cell lymphoma protein 2 alpha
- B-cell lymphoma protein 2 beta
|
| Category | - Amplification in Prostate cancer
|
| UniGene | Hs.79241 |
| OMIM | 151430 |
| Locus | 596 |
| Summary | BCL2 is an integral inner mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. Variant 1 is represented by a 5.5 kb mRNA and includes most of exon 1 and exon 2. A 3.5 kb mRNA represents variant 2; it includes all of exon 1 and lacks exon 2 sequence. |
| Gene Ontology | |
| Expression | | EST (150 ESTs, 71 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (2/27) |  | 3/40686 |
| bone marrow (3/263) | | 3/38555 |
| brain (3/204) | | 4/362011 |
| cartilage (1/5) | | 1/11018 |
| colon (1/853) | | 1/165626 |
| ear (1/2) | | 1/12660 |
| embryo (2/19) | | 6/37976 |
| foreskin (1/4) | | 6/20040 |
| germ cell (2/7) | | 5/57383 |
| head and neck (3/990) | | 3/79796 |
| heart (2/22) | | 4/55494 |
| kidney (5/86) | | 12/132968 |
| lung (5/312) | | 7/245386 |
| muscle (2/21) | | 2/71297 |
| ovary (2/144) | | 5/81880 |
| parathyroid (1/4) | | 2/19377 |
| placenta (6/342) | | 11/157762 |
| prostate (2/291) |  | 3/109871 |
| skin (1/31) | | 4/100815 |
| stomach (2/312) | | 7/129930 |
| testis (2/171) | | 13/117531 |
| thyroid (1/24) | | 1/6853 |
| uncharacterized tissue (19/1773) | | 44/713325 |
| uterus (2/212) | | 2/155110 |
|
| SAGE (1497842 tags, 28 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| brain (5/19) | | 6/376489 |
| eye (2/6) | | 2/156025 |
| lung (1/1) | | 1/89143 |
| mammary gland (4/19) | | 4/191470 |
| ovary (2/10) | | 2/66037 |
| pancreas (1/8) | | 1/47061 |
| prostate (6/13) | | 9/343129 |
| stomach (1/3) | | 1/70433 |
| uncharacterized tissue (4/22) | | 5/158055 |
|
|
| Evidence | Amplification in Prostate cancer
|
