| Name | transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C) |
| Symbol | TCEB1 |
| Aliases | SIII; transcription elongation factor B, polypeptide 1 |
| Gene Product | |
| Category | - Amplification in Prostate cancer
|
| UniGene | Hs.184693 |
| OMIM | 600788 |
| Locus | 6921 |
| Summary | This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. |
| Gene Ontology | |
| Expression | | EST (304 ESTs, 127 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| b cells (1/1) |  | 3/16734 |
| blood (5/27) | | 7/40686 |
| bone (1/13) | | 3/26211 |
| brain (16/204) | | 38/362011 |
| colon (8/853) | | 11/165626 |
| ear (1/2) | | 2/12660 |
| embryo (1/19) | | 3/37976 |
| eye (5/33) | | 7/93836 |
| germ cell (3/7) | | 4/57383 |
| head and neck (1/990) | | 1/79796 |
| heart (1/22) | | 14/55494 |
| intestine (1/4) | | 1/11528 |
| kidney (7/86) | | 11/132968 |
| liver (1/38) | | 1/46472 |
| lung (9/312) | | 23/245386 |
| muscle (4/21) | | 4/71297 |
| nervous (3/475) | | 5/43438 |
| oral cavity (1/18) | | 6/44567 |
| ovary (3/144) | | 5/81880 |
| pancreas (4/33) | | 14/117255 |
| parathyroid (1/4) | | 4/19377 |
| placenta (2/342) | | 4/157762 |
| prostate (4/291) |  | 6/109871 |
| skin (4/31) | | 10/100815 |
| stomach (8/312) | | 10/129930 |
| testis (4/171) | | 33/117531 |
| uncharacterized tissue (23/1773) | | 61/713325 |
| uterus (4/212) | | 11/155110 |
|
| SAGE (14414120 tags, 274 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 4/145569 |
| brain (19/19) | | 98/3160385 |
| cerebellum (1/1) | | 4/102560 |
| colon (6/8) | | 30/854130 |
| eye (5/6) | | 31/851527 |
| foreskin (2/2) | | 3/19256 |
| heart (1/1) | | 22/253071 |
| kidney (2/2) | | 13/202247 |
| liver (1/1) | | 2/133722 |
| lung (1/1) | | 11/267429 |
| mammary gland (12/19) | | 50/1558386 |
| muscle (2/2) | | 7/161603 |
| ovary (9/10) | | 45/873635 |
| pancreas (8/8) | | 35/490903 |
| prostate (12/13) | | 82/1966661 |
| skin (5/7) | | 11/129953 |
| stomach (3/3) | | 13/596464 |
| uncharacterized tissue (18/22) | | 70/1805283 |
| vascular (3/3) | | 30/841336 |
|
|
| SNP | rs3032972 (-/AA:mrna-utr); rs1277916 (T/G:intron); rs922752 (A/C:intron); rs2957588 (C/G:mrna-utr); rs900130 (A/G:intron); rs1559797 (A/G:intron); rs2929504 (T/C:mrna-utr); |
| Evidence | Amplification in Prostate cancer
|
