| Name | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| Symbol | CDKN1A |
| Aliases | P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; DNA synthesis inhibitor; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6 |
| Gene Product | - cyclin-dependent kinase inhibitor 1A
|
| Category | - Methylation in Prostate cancer
- Mutation in Prostate cancer
- Polymorphism in Prostate cancer
|
| UniGene | Hs.179665 |
| OMIM | 116899 |
| Locus | 1026 |
| Summary | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. |
| Gene Ontology | |
| Expression | | EST (747 ESTs, 232 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| adipose (1/10) |  | 2/2445 |
| adrenal gland (1/15) | | 1/17521 |
| blood (4/27) | | 5/40686 |
| bone (2/13) | | 9/26211 |
| brain (16/204) | | 50/362011 |
| cartilage (2/5) | | 5/11018 |
| cervix (2/7) | | 13/28115 |
| colon (17/853) | | 37/165626 |
| ear (1/2) | | 4/12660 |
| embryo (2/19) | | 2/37976 |
| esophagus (1/6) | | 1/3022 |
| eye (5/33) | | 30/93836 |
| foreskin (1/4) | | 15/20040 |
| germ cell (4/7) | | 6/57383 |
| head and neck (9/990) | | 9/79796 |
| heart (2/22) | | 13/55494 |
| intestine (2/4) | | 5/11528 |
| kidney (8/86) | | 21/132968 |
| liver (3/38) | | 10/46472 |
| lung (30/312) | | 140/245386 |
| muscle (4/21) | | 14/71297 |
| nervous (4/475) | | 7/43438 |
| ovary (3/144) | | 6/81880 |
| pancreas (9/33) | | 44/117255 |
| parathyroid (1/4) | | 2/19377 |
| placenta (11/342) | | 35/157762 |
| prostate (5/291) |  | 9/109871 |
| skin (7/31) | | 34/100815 |
| stomach (14/312) | | 61/129930 |
| testis (4/171) | | 14/117531 |
| thymus (1/17) | | 1/5021 |
| thyroid (2/24) | | 2/6853 |
| uncharacterized tissue (44/1773) | | 107/713325 |
| uterus (9/212) | | 32/155110 |
|
| SAGE (1185809 tags, 21 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| brain (5/19) | | 5/293575 |
| colon (1/8) | | 1/52094 |
| eye (2/6) | | 4/263357 |
| foreskin (1/2) | | 1/9759 |
| mammary gland (3/19) | | 3/184114 |
| pancreas (1/8) | | 1/32512 |
| prostate (1/13) | | 1/68626 |
| stomach (1/3) | | 2/70433 |
| uncharacterized tissue (4/22) | | 4/211339 |
|
|
| SNP | rs762623 (A/C:locus-region); rs2894408 (C/T:mrna-utr); rs2395655 (A/G:locus-region); rs733590 (C/T:locus-region); rs730506 (C/G:locus-region); |
| Evidence | Methylation in Prostate cancer
Mutation in Prostate cancer
Polymorphism in Prostate cancer
|
