Human

Human Prostate Gene DataBase

Name non-metastatic cells 1, protein (NM23A) expressed in
Symbol NME1
Aliases NM23; NM23-H1
Gene Product
  • non-metastatic cells 1 protein
Category
  • Mutation in Prostate cancer
UniGeneHs.118638
OMIM156490
Locus4830
SummaryNME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. NME1 encodes the 'A' isoform of nucleoside diphosphate kinase (NDK). NDK exists as a hexamer composed of the 'A' (NME1) and 'B' (encoded by NME2) isoforms. Mutations in NME1 have been identified in aggressive neuroblastomas.
Expression
EST (451 ESTs, 176 libraries)
Tissue ? Frequency ? Count ?
adrenal gland (3/15)0.007 4/17521
b cells (1/1)0.003 2/16734
blood (8/27)0.012 19/40686
bone (1/13)0.019 7/26211
bone marrow (2/263)0.003 2/38555
brain (20/204)0.007 59/362011
colon (16/853)0.005 22/165626
embryo (2/19)0.024 2/37976
eye (5/33)0.003 22/93836
germ cell (1/7)0.003 1/57383
head and neck (3/990)0.100 3/79796
heart (1/22)0.003 5/55494
intestine (1/4)0.002 1/11528
kidney (8/86)0.006 11/132968
liver (2/38)0.003 3/46472
lung (11/312)0.005 41/245386
muscle (2/21)0.002 5/71297
nervous (2/475)0.412 2/43438
oral cavity (1/18)0.001 1/44567
ovary (2/144)0.012 5/81880
pancreas (4/33)0.014 17/117255
parathyroid (1/4)0.003 3/19377
placenta (3/342)0.006 16/157762
prostate (6/291)0.001 10/109871
skin (6/31)0.002 48/100815
stomach (14/312)0.012 24/129930
testis (6/171)0.057 17/117531
thymus (1/17)0.028 1/5021
umbilical cord (1/3)0.018 5/6185
uncharacterized tissue (34/1773)0.049 74/713325
uterus (8/212)1.000 19/155110
SAGE (32451410 tags, 661 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)0.085 4/97046
brain (19/19)0.598 719/6872882
cerebellum (1/1)0.211 10/256400
colon (8/8)0.455 227/1797779
eye (5/6)0.425 142/2281171
foreskin (2/2)0.394 8/48271
heart (1/1)0.453 40/674856
kidney (2/2)1.000 72/337597
liver (1/1)0.210 17/334305
lung (1/1)0.462 42/624001
mammary gland (19/19)0.903 810/4651155
muscle (2/2)0.280 34/269309
ovary (10/10)0.779 242/1546889
pancreas (8/8)0.760 239/1466108
prostate (13/13)0.919 652/3931557
skin (7/7)0.869 89/434292
stomach (3/3)0.477 90/1026760
uncharacterized tissue (22/22)0.644 536/4859963
vascular (3/3)0.761 160/941069
EvidenceMutation in Prostate cancer

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Department of Urology
Universityof California, San Francisco