Human

Human Prostate Gene DataBase
Name hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Symbol HIF1A
Aliases MOP1; HIF-1ALPHA; HIF1-ALPHA
Gene Product
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Category
  • Amplification in Prostate cancer
UniGeneHs.197540
OMIM603348
Locus3091
SummaryBasic helix-loop-helix transcription factor; mediates transcriptional responses to hypoxia and dioxin-signaling; contains a PAS domain
Gene Ontology
Expression
EST (428 ESTs, 191 libraries)
Tissue ? Frequency ? Count ?
adipose (1/10)0.025 1/2445
adrenal gland (4/15)0.010 5/17521
blood (2/27)0.027 4/40686
bone (6/13)0.008 18/26211
bone marrow (4/263)0.007 5/38555
brain (14/204)0.006 26/362011
cartilage (1/5)0.007 1/11018
cervix (2/7)0.004 2/28115
colon (7/853)0.043 16/165626
ear (1/2)0.002 1/12660
embryo (2/19)0.004 10/37976
esophagus (1/6)0.009 1/3022
eye (1/33)0.008 5/93836
foreskin (1/4)0.001 1/20040
head and neck (14/990)0.273 18/79796
heart (1/22)0.002 1/55494
intestine (1/4)0.005 2/11528
kidney (9/86)0.007 15/132968
liver (1/38)0.009 3/46472
lung (11/312)0.028 30/245386
muscle (4/21)1.000 9/71297
nervous (4/475)0.217 11/43438
oral cavity (1/18)0.003 5/44567
ovary (3/144)0.012 6/81880
pancreas (7/33)0.004 22/117255
placenta (6/342)0.003 14/157762
prostate (3/291)0.007 9/109871
skin (4/31)0.003 14/100815
spleen (1/7)0.012 1/9511
stomach (12/312)0.027 24/129930
testis (5/171)0.063 14/117531
thyroid (1/24)0.056 1/6853
umbilical cord (1/3)0.008 2/6185
uncharacterized tissue (41/1773)0.049 102/713325
uterus (9/212)0.006 22/155110
SAGE (19913707 tags, 371 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)1.000 29/485230
brain (19/19)0.171 133/4725782
cerebellum (1/1)0.224 8/205120
colon (7/8)0.073 19/1057210
eye (5/6)0.169 34/1746596
foreskin (1/2)0.271 1/9759
heart (1/1)0.058 4/337428
kidney (2/2)0.202 9/253883
liver (1/1)0.092 5/200583
lung (1/1)0.178 10/534858
mammary gland (17/19)0.178 92/2509914
ovary (8/10)0.280 63/1206235
pancreas (7/8)0.146 25/657145
prostate (12/13)0.170 59/1790046
skin (4/7)0.112 4/63709
stomach (3/3)0.120 15/464400
uncharacterized tissue (20/22)0.174 83/2608732
vascular (3/3)0.265 31/1057077
SNPrs2057481 (C/T:mrna-utr);  rs2165601 (A/G:locus-region);  rs1254677 (C/T:locus-region);  rs1015447 (C/T:intron);  rs1802821 (A/G:coding-nonsyn);  rs2255627 (A/G:locus-region);  rs962962 (A/G:intron);  rs2028519 (A/G:locus-region);  rs1661436 (G/C:locus-region);  rs2352539 (A/T:intron);  rs2284999 (C/T:locus-region);  rs2761143 (T/C:locus-region);  rs1967773 (C/T:intron);  rs2301104 (A/G:locus-region);  rs1040995 (A/G:intron);  rs1957754 (C/T:intron);  rs1319462 (A/G:locus-region);  rs2882968 (C/T:locus-region);  rs2181600 (T/G:intron);  rs3062103 (AAAC/-:intron);  rs1152572 (G/A:locus-region);  rs1555584 (C/T:intron);  rs966824 (C/T:intron);  rs2274012 (A/G:locus-region);  rs994740 (C/T:locus-region);  rs1951795 (A/C:intron);  rs984788 (C/T:locus-region);  
EvidenceAmplification in Prostate cancer
© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco