| Name | MAD1 mitotic arrest deficient-like 1 (yeast) |
| Symbol | MAD1L1 |
| Aliases | MAD1; HsMAD1; TXBP181; mitotic-arrest deficient 1, yeast, homolog-like 1; MAD1 (mitotic arrest deficient, yeast, homolog)-like 1 |
| Gene Product | |
| Category | - Mutation in Prostate cancer
|
| UniGene | Hs.7345 |
| OMIM | 602686 |
| Locus | 8379 |
| Summary | MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. |
| Gene Ontology | |
| Expression | | EST (200 ESTs, 84 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| b cells (1/1) |  | 3/16734 |
| blood (2/27) | | 8/40686 |
| bone (1/13) | | 1/26211 |
| brain (13/204) | | 19/362011 |
| cartilage (1/5) | | 1/11018 |
| cervix (1/7) | | 2/28115 |
| colon (5/853) | | 5/165626 |
| eye (2/33) | | 4/93836 |
| foreskin (1/4) | | 2/20040 |
| head and neck (2/990) | | 3/79796 |
| heart (1/22) | | 3/55494 |
| kidney (6/86) | | 8/132968 |
| liver (2/38) | | 6/46472 |
| lung (4/312) | | 4/245386 |
| muscle (2/21) | | 2/71297 |
| oral cavity (1/18) | | 1/44567 |
| ovary (1/144) | | 2/81880 |
| pancreas (3/33) | | 6/117255 |
| placenta (2/342) | | 4/157762 |
| prostate (2/291) |  | 2/109871 |
| skin (5/31) | | 27/100815 |
| stomach (4/312) | | 4/129930 |
| testis (5/171) | | 10/117531 |
| thymus (1/17) | | 2/5021 |
| uncharacterized tissue (13/1773) | | 68/713325 |
| uterus (3/212) | | 3/155110 |
|
| SAGE (5816562 tags, 112 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 3/48523 |
| brain (16/19) | | 39/1558825 |
| cerebellum (1/1) | | 1/51280 |
| colon (7/8) | | 11/452579 |
| eye (2/6) | | 2/112234 |
| heart (1/1) | | 1/84357 |
| kidney (1/2) | | 4/96234 |
| liver (1/1) | | 2/66861 |
| lung (1/1) | | 1/89143 |
| mammary gland (8/19) | | 16/530666 |
| muscle (1/2) | | 3/107750 |
| ovary (7/10) | | 11/212352 |
| pancreas (4/8) | | 6/161687 |
| prostate (8/13) | | 18/713496 |
| skin (5/7) | | 6/71306 |
| stomach (2/3) | | 7/202497 |
| uncharacterized tissue (13/22) | | 22/1088185 |
| vascular (2/3) | | 3/168587 |
|
|
| SNP | rs1620530 (A/G:locus-region); rs735932 (C/G:locus-region); rs731140 (A/G:locus-region); rs1625464 (C/T:locus-region); rs2079566 (C/T:locus-region); rs1612548 (A/G:locus-region); rs1624785 (A/G:locus-region); rs1632674 (G/C:locus-region); rs879672 (G/T:locus-region); rs1558457 (A/C:locus-region); rs1618820 (T/C:locus-region); rs2159782 (A/G:locus-region); rs749991 (A/G:locus-region); rs733611 (C/T:locus-region); rs1637728 (G/A:locus-region); rs2241007 (T/G:locus-region); rs2108556 (G/A:locus-region); rs3076522 (-/TCC:locus-region); rs2098207 (C/A:locus-region); rs745528 (A/G:locus-region); rs1002169 (C/T:locus-region); rs2058430 (A/G:locus-region); rs878851 (A/G:locus-region); rs2398704 (A/G:locus-region); rs1621778 (T/C:locus-region); rs1626670 (G/A:locus-region); rs1543888 (A/G:locus-region); rs1860826 (A/G:locus-region); rs2080022 (A/C:locus-region); rs2159044 (A/G:locus-region); rs1476887 (C/T:locus-region); rs1625543 (G/A:locus-region); rs1859991 (C/T:locus-region); rs2109905 (T/C:locus-region); rs749870 (A/G:locus-region); rs1639895 (A/G:locus-region); rs1004643 (C/G:locus-region); rs745565 (A/G:locus-region); rs1614599 (T/G:locus-region); |
| Evidence | Mutation in Prostate cancer
|
