Human

Human Prostate Gene DataBase
Name glutathione S-transferase pi
Symbol GSTP1
Aliases PI; DFN7; GST3; FAEES3; deafness, X-linked 7; fatty acid ethyl ester synthase III
Gene Product
  • glutathione transferase
Category
  • Methylation in Prostate cancer
  • Polymorphism in Prostate cancer
UniGeneHs.226795
OMIM134660
Locus2950
SummaryGlutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
Gene Ontology
Expression
EST (1062 ESTs, 283 libraries)
Tissue ? Frequency ? Count ?
adrenal gland (3/15)0.089 5/17521
b cells (1/1)0.006 6/16734
blood (4/27)0.003 17/40686
bone (2/13)0.010 8/26211
bone marrow (1/263)0.061 2/38555
brain (16/204)0.006 95/362011
cartilage (2/5)0.005 3/11018
cervix (3/7)0.017 3/28115
colon (28/853)0.046 109/165626
embryo (2/19)0.002 5/37976
esophagus (1/6)0.012 2/3022
eye (10/33)1.000 49/93836
foreskin (1/4)0.007 8/20040
germ cell (3/7)0.032 8/57383
head and neck (17/990)0.065 63/79796
heart (3/22)0.075 13/55494
intestine (1/4)0.008 5/11528
kidney (7/86)0.009 26/132968
liver (3/38)0.003 4/46472
lung (26/312)0.011 73/245386
muscle (4/21)0.041 15/71297
nervous (1/475)0.037 1/43438
oral cavity (3/18)0.028 6/44567
ovary (7/144)0.061 20/81880
pancreas (9/33)0.013 51/117255
parathyroid (1/4)0.003 3/19377
placenta (10/342)0.005 86/157762
prostate (12/291)0.002 32/109871
skin (7/31)0.002 22/100815
spleen (1/7)0.007 2/9511
stomach (17/312)0.288 106/129930
testis (6/171)0.002 16/117531
thymus (1/17)0.321 1/5021
thyroid (3/24)0.038 6/6853
umbilical cord (1/3)0.006 2/6185
uncharacterized tissue (45/1773)0.014 120/713325
uterus (19/212)0.001 67/155110
SAGE (3982598 tags, 74 libraries)
Tissue ? Frequency ? Count ?
brain (13/19)0.351 18/925736
cerebellum (1/1)0.784 2/102560
colon (3/8)0.444 4/200401
eye (4/6)0.564 11/536684
liver (1/1)0.100 1/66861
lung (1/1)0.226 1/89143
mammary gland (5/19)0.350 5/242807
muscle (1/2)0.373 1/53853
ovary (4/10)1.000 6/218373
pancreas (4/8)0.330 4/131540
prostate (5/13)0.453 13/425070
skin (1/7)0.665 1/10080
stomach (2/3)0.392 5/272930
uncharacterized tissue (12/22)0.493 16/706560
SNPrs947894 (A/C:locus-region);  rs1871041 (C/T:intron);  rs762803 (A/C:intron);  rs1079719 (A/G:intron);  rs675554 (T/C:intron);  rs4891 (T/C:coding-nonsyn);  rs3082937 (-/CGTGTG:intron);  rs2370143 (C/T:intron);  rs1065670 (C/T:mrna-utr);  rs749174 (C/T:intron);  
EvidenceMethylation in Prostate cancer Polymorphism in Prostate cancer
© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco